Structure of pentameric human serum amyloid P component

Jonas Emsley; Helen E. White; Bernard P. O'hara; Glaucius Oliva; Narayanaswamy Srinivasan; Ian J. Tickle; Tom L. Blundell; Mark B. Pepys; Steve P. Wood

doi:10.1038/367338a0

Structure of pentameric human serum amyloid P component

Jonas Emsley, Helen E. White, Bernard P. O'hara, Glaucius Oliva, Narayanaswamy Srinivasan, Ian J. Tickle, Tom L. Blundell, Mark B. Pepys, Steve P. Wood

Institute of Life Sciences and Healthcare

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Abstract

The three-dimensional structure of pentameric human serum amyloid P component at high resolution, the first reported for a pentraxin, reveals that the tertiary fold is remarkably similar to that of the legume lectins. Carboxylate and phosphate compounds bind directly to two calcium ions; interactions with a carboxyethylidene ring are mediated by Asn 59 and Gin 148 ligands of the calcium ions. These X-ray results indicate the probable modes of binding of the biologically important ligands, DNA and amyloid fibrils.

Original language	English
Pages (from-to)	338-345
Journal	Nature
Volume	367
Issue number	6461
DOIs	https://doi.org/10.1038/367338a0
Publication status	Published - 27 Jan 1994

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title = "Structure of pentameric human serum amyloid P component",

abstract = "The three-dimensional structure of pentameric human serum amyloid P component at high resolution, the first reported for a pentraxin, reveals that the tertiary fold is remarkably similar to that of the legume lectins. Carboxylate and phosphate compounds bind directly to two calcium ions; interactions with a carboxyethylidene ring are mediated by Asn 59 and Gin 148 ligands of the calcium ions. These X-ray results indicate the probable modes of binding of the biologically important ligands, DNA and amyloid fibrils.",

author = "Jonas Emsley and White, {Helen E.} and O'hara, {Bernard P.} and Glaucius Oliva and Narayanaswamy Srinivasan and Tickle, {Ian J.} and Blundell, {Tom L.} and Pepys, {Mark B.} and Wood, {Steve P.}",

year = "1994",

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AU - Emsley, Jonas

AU - White, Helen E.

AU - O'hara, Bernard P.

AU - Oliva, Glaucius

AU - Srinivasan, Narayanaswamy

AU - Tickle, Ian J.

AU - Blundell, Tom L.

AU - Pepys, Mark B.

AU - Wood, Steve P.

PY - 1994/1/27

Y1 - 1994/1/27

N2 - The three-dimensional structure of pentameric human serum amyloid P component at high resolution, the first reported for a pentraxin, reveals that the tertiary fold is remarkably similar to that of the legume lectins. Carboxylate and phosphate compounds bind directly to two calcium ions; interactions with a carboxyethylidene ring are mediated by Asn 59 and Gin 148 ligands of the calcium ions. These X-ray results indicate the probable modes of binding of the biologically important ligands, DNA and amyloid fibrils.

AB - The three-dimensional structure of pentameric human serum amyloid P component at high resolution, the first reported for a pentraxin, reveals that the tertiary fold is remarkably similar to that of the legume lectins. Carboxylate and phosphate compounds bind directly to two calcium ions; interactions with a carboxyethylidene ring are mediated by Asn 59 and Gin 148 ligands of the calcium ions. These X-ray results indicate the probable modes of binding of the biologically important ligands, DNA and amyloid fibrils.

U2 - 10.1038/367338a0

DO - 10.1038/367338a0

M3 - Article

SN - 0028-0836

VL - 367

SP - 338

EP - 345

JO - Nature

JF - Nature

IS - 6461

ER -

Structure of pentameric human serum amyloid P component

Abstract

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