Free radical scavenging: A potentially beneficial action of thiol-containing angiotensin converting enzyme inhibitors

M. Chopra; J. McMurray; J. Stewart; H. J. Dargie; W. E. Smith

doi:10.1042/bst0181184

Free radical scavenging: A potentially beneficial action of thiol-containing angiotensin converting enzyme inhibitors

M. Chopra, J. McMurray, J. Stewart, H. J. Dargie, W. E. Smith

University of Strathclyde

Research output: Contribution to journal › Review article › peer-review

Abstract

Free radical (FR) scavenging may be a therapeutically useful adjunctive property of angiotensin converting enzyme (ACE) inhibitors. In this study we have shown that SH-containing ACE inhibitors (captopril, epicaptopril, zofenopril) are potent FR scavengers at a concentration of 4 x 10^-5 M whereas non-SH ACE inhibitors (enalaprilat, quinaprilat and perindoprilat) have no FR-scavenging activity at this concentration. Furthermore, the SH-containing agents preferentially scavenged general radicals rather than superoxide radicals, i.e. suggesting that these drugs would be effective in quenching the culprit FR in ischaemia/reperfusion injury.

Original language	English
Pages (from-to)	1184-1185
Number of pages	2
Journal	Biochemical Society Transactions
Volume	18
Issue number	6
DOIs	https://doi.org/10.1042/bst0181184
Publication status	Published - 1 Dec 1990

Keywords

angiotensin converting enzyme
ACE
free radical
FR

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10.1042/bst0181184

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title = "Free radical scavenging: A potentially beneficial action of thiol-containing angiotensin converting enzyme inhibitors",

abstract = "Free radical (FR) scavenging may be a therapeutically useful adjunctive property of angiotensin converting enzyme (ACE) inhibitors. In this study we have shown that SH-containing ACE inhibitors (captopril, epicaptopril, zofenopril) are potent FR scavengers at a concentration of 4 x 10-5 M whereas non-SH ACE inhibitors (enalaprilat, quinaprilat and perindoprilat) have no FR-scavenging activity at this concentration. Furthermore, the SH-containing agents preferentially scavenged general radicals rather than superoxide radicals, i.e. suggesting that these drugs would be effective in quenching the culprit FR in ischaemia/reperfusion injury.",

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T2 - A potentially beneficial action of thiol-containing angiotensin converting enzyme inhibitors

AU - Chopra, M.

AU - McMurray, J.

AU - Stewart, J.

AU - Dargie, H. J.

AU - Smith, W. E.

PY - 1990/12/1

Y1 - 1990/12/1

N2 - Free radical (FR) scavenging may be a therapeutically useful adjunctive property of angiotensin converting enzyme (ACE) inhibitors. In this study we have shown that SH-containing ACE inhibitors (captopril, epicaptopril, zofenopril) are potent FR scavengers at a concentration of 4 x 10-5 M whereas non-SH ACE inhibitors (enalaprilat, quinaprilat and perindoprilat) have no FR-scavenging activity at this concentration. Furthermore, the SH-containing agents preferentially scavenged general radicals rather than superoxide radicals, i.e. suggesting that these drugs would be effective in quenching the culprit FR in ischaemia/reperfusion injury.

AB - Free radical (FR) scavenging may be a therapeutically useful adjunctive property of angiotensin converting enzyme (ACE) inhibitors. In this study we have shown that SH-containing ACE inhibitors (captopril, epicaptopril, zofenopril) are potent FR scavengers at a concentration of 4 x 10-5 M whereas non-SH ACE inhibitors (enalaprilat, quinaprilat and perindoprilat) have no FR-scavenging activity at this concentration. Furthermore, the SH-containing agents preferentially scavenged general radicals rather than superoxide radicals, i.e. suggesting that these drugs would be effective in quenching the culprit FR in ischaemia/reperfusion injury.

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KW - ACE

KW - free radical

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JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

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Free radical scavenging: A potentially beneficial action of thiol-containing angiotensin converting enzyme inhibitors

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Keywords

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